Pheochromocytoma
Definition : Catecholamine secreting tumour derived from chromaffin cells of adrenal gland.
Pathophysiology : tumour secretes catecholamine which includes epinephrine, norepinephrine and rarely dopamine
Effect :
- Stimulation of alpha adrenergic receptors cause : elevated blood pressure, increased cardiac contractility, glycogenolysis, gluconeogenesis and intestinal relaxation
- Stimulation of beta adrenergic receptors cause : increase heart rate and contractility
Symptoms:
- Headache
- palpitation
- diaphoresis
- severe hypertension
- Constipation
- anxiety
- Flank pain
- epigastric pain
- nausea
- weight loss
- tremor
Signs:
- weight loss
- neurofibroma
- cafe au lait spots
- pallor
- tremor
- fever hypertension
- tachyarrhythmias
- pulmonary odema
- cardiomyopathy
- ileus
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