Spiga

Pheochromocytoma


Pheochromocytoma 


Definition : Catecholamine secreting tumour derived from chromaffin cells of adrenal gland.

Pathophysiology : tumour secretes catecholamine  which includes epinephrine, norepinephrine and rarely dopamine
Effect :
  • Stimulation of alpha adrenergic receptors cause : elevated blood pressure, increased cardiac contractility, glycogenolysis, gluconeogenesis and intestinal relaxation
  • Stimulation of beta adrenergic receptors cause : increase heart rate and contractility
Symptoms:
  • Headache
  • palpitation
  • diaphoresis
  • severe hypertension
  • Constipation
  • anxiety
  • Flank pain 
  • epigastric pain
  • nausea
  • weight loss
  • tremor
Signs:
  • weight loss
  • neurofibroma
  • cafe au lait spots
  • pallor
  • tremor
  • fever hypertension
  • tachyarrhythmias
  • pulmonary odema
  • cardiomyopathy
  • ileus

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